| dc.description.abstract | As subsequent chapters will describe, the vertebrate nervous system
is necessarily complex. However, this belies its humble
beginnings, segregating relatively early as a plate of cells in the
dorsal ectoderm of the embryo. This process of segregation,
termed neural induction, occurs as a result of instructive cues
within the embryo and is described in this chapter. Once induced,
the neural plate, in most vertebrates, rolls into a tube during a
process known as neurulation. This tube is then later elaborated
to form the central nervous system. In this chapter, we describe
the model for how ectodermal cells become committed to a
neural fate, and the studies that have led to this model. We will
then review the mechanisms by which the induced neural ectoderm
rolls up to form the neural tube. | en_US |
