| dc.description.abstract | A model that takes into account multi-mutation and drug resistance in a case of simple
immune system and immune-suppression caused by drug resistant tumor cells
is proposed. Since methods for revising therapeutic approaches (immunotherapy
and chemotherapy) during cancer treatment are still being explored, we analyzed
mathematically and simulated numerically with the aid of MATLAB software the
corresponding tumor-immunotherapy model to determine the effectiveness of the
immunotherapy. Through the mathematical analysis, the existence, the uniqueness
and the boundedness of solutions are shown. The non-tumor states are stable, under
conditions only in the presence of the immunotherapy drug and in the absence
of the drug resistant tumor cells. The numerical results show the behavior of the
tumor cells and immune system cells in the absence and in the presence of the
immunotherapy drug. This study provides an efficient treatment strategie to cancer
in the absence and in the presence of the drug resistant tumor cells. | en_US |
